Description

1,4-Diiodo-2-Fluorobenzene is a high-purity halogenated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of iodine and fluorine atoms, which serve as versatile handles for further functionalization via cross-coupling reactions. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated or iodinated aromatic cores for enhanced bioavailability or metabolic stability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the diiodo-fluorobenzene scaffold can impart specific biological activity.
• Material Science Research: Serves as a monomer or building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atoms are excellent substrates for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings, enabling rapid diversification of chemical libraries.
• Fluorine Chemistry: The presence of fluorine allows for study and application in the growing field of fluorochemistry, useful in PET imaging agent development and other diagnostic applications.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	1,4-Diiodo-2-Fluorobenzene
CAS No.	147808-02-4
Molecular Formula	C6H3FI2
Molecular Weight	347.89 g/mol
Synonyms	2-Fluoro-1,4-diiodobenzene; 1,4-Diiodo-2-fluorobenzene; 2-Fluorobenzene-1,4-diyl diiodide; p-Diiodo-o-fluorobenzene; 4-Fluoro-1,2-diiodobenzene (isomer); Benzene, 1,4-diiodo-2-fluoro-; FDBM (common abbreviation in some contexts)
EINECS	Contact for details

Quality Control

Our 1,4-Diiodo-2-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and transfers should be minimized under direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.