Description

8-(3-Chlorostyryl) Caffeine is a potent and selective antagonist of the A2A adenosine receptor, a key target in neurological and cardiovascular research. This high-purity biochemical is essential for studying adenosine signaling pathways, receptor function, and for the preclinical development of novel therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on CNS disorders, inflammation, and immuno-oncology.

Application

• Neurological Research: Investigation of Parkinson's disease, sleep disorders, and neuroprotection mechanisms via A2A receptor blockade.
• Cardiovascular Studies: Research into coronary artery function, myocardial ischemia, and regulation of blood flow.
• Immunology & Inflammation: Study of anti-inflammatory effects and modulation of immune cell responses.
• Oncology Research: Exploration of adenosine's role in the tumor microenvironment and potential for immuno-oncology therapeutics.
• Pharmacological Profiling: Used as a reference standard in high-throughput screening (HTS) and binding assays to identify new drug candidates.
• Biochemical Pathway Analysis: Tool for elucidating the role of adenosine receptors in various signal transduction cascades.

Basic Information

Product Name	8-(3-Chlorostyryl) Caffeine
CAS No.	147700-11-6
Molecular Formula	C18H17ClN4O2
Molecular Weight	356.81 g/mol
Synonyms	CSC; 8-(3-Chlorostyryl)caffeine; 8-[(E)-2-(3-Chlorophenyl)ethenyl]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione; A2A Adenosine Receptor Antagonist; 1,3,7-Trimethyl-8-[(E)-2-(3-chlorophenyl)ethenyl]-3,7-dihydro-1H-purine-2,6-dione; 8-(3-Chlorostyryl)-1,3,7-trimethylxanthine; KW-6002 (research code)
EINECS	Contact for details

Quality Control

Supplied as a high-purity research-grade biochemical, our 8-(3-Chlorostyryl) Caffeine undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all critical quality parameters. Our quality management system ensures traceability and consistency for reliable research outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.