Description

1-(Chloromethyl)-2-Fluoro-4-Methylbenzene is a versatile aromatic building block featuring both chloromethyl and fluorine substituents, which are key functional groups for further chemical synthesis. This compound is valued for its role in introducing reactive sites into complex molecules, enabling the creation of advanced intermediates for pharmaceuticals and agrochemicals. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for constructing active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those requiring fluorinated or benzyl-chloride motifs for further functionalization.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic compounds used in electronic display technologies.
• Polymer Modification Agent: Employed to introduce reactive chloromethyl groups into polymer chains for subsequent cross-linking or grafting reactions.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create biaryl structures.
• Organic Synthesis Reagent: Utilized in laboratories for the preparation of benzyl ethers, amines, and other derivatives via nucleophilic substitution of the chloromethyl group.

Basic Information

Product Name	1-(Chloromethyl)-2-Fluoro-4-Methylbenzene
CAS No.	147541-99-9
Molecular Formula	C8H8ClF
Molecular Weight	158.60 g/mol
Synonyms	2-Fluoro-4-methylbenzyl chloride; 2-Fluoro-α-chloro-p-xylene; 4-Methyl-2-fluorobenzyl chloride; (2-Fluoro-4-methylphenyl)methyl chloride; 1-Chloromethyl-2-fluoro-4-methylbenzene; α-Chloro-2-fluoro-p-xylene; 2-Fluoro-4-methylbenzylchloride; Benzene, 1-(chloromethyl)-2-fluoro-4-methyl-
EINECS	Contact for details

Quality Control

Our 1-(Chloromethyl)-2-Fluoro-4-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, keep the container tightly sealed to minimize exposure to atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.