Description

Pyripyropene A is a potent and naturally occurring fungal metabolite belonging to the pyripyropene class of compounds. This molecule is of significant interest in life science research due to its specific biological activity as a selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). It serves as a critical research tool for scientists in the pharmaceutical and biotechnology sectors investigating lipid metabolism, atherosclerosis, and novel therapeutic pathways. The compound is supplied under the identifier CAS 147444-03-9.

Application

• Pharmaceutical Research & Development: A key reference standard and pharmacological tool for studying cholesterol esterification and ACAT enzyme function.
• Biochemical Assay Development: Used as a selective inhibitor to establish and validate high-throughput screening assays for drug discovery targeting metabolic diseases.
• Academic Research: Employed in university and institutional labs for fundamental studies on lipid biology, cell signaling, and the pathophysiology of cardiovascular conditions.
• Mechanism of Action (MoA) Studies: Essential for elucidating the biological pathways and cellular targets of new chemical entities in pre-clinical development.
• Bioactive Natural Product Sourcing: Sourced as a high-purity natural product lead compound for medicinal chemistry and analog synthesis programs.

Basic Information

Product Name	Pyripyropene A
CAS No.	147444-03-9
Molecular Formula	C₂₃H₂₇NO₈
Molecular Weight	445.46 g/mol
Synonyms	Pyripyropene A; (3S,4R,4aR,6aS,7R,9aS,10aR,10bS)-4,7-Bis(acetyloxy)-3-[(1E)-3-ethoxy-3-oxo-1-propen-1-yl]-1,2,3,4,4a,5,6,6a,7,9a,10,10a,10b,11-tetradecahydro-8,10b-dihydroxy-6a,10a-dimethyl-9-oxo-4,7-methanocyclopenta[4,5]cyclodeca[1,2-b]furan-11-carboxylic acid methyl ester; ACAT Inhibitor Pyripyropene A; Mer F2; FR 111142; Pyripyropene
EINECS	Contact for details

Quality Control

Our Pyripyropene A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.