Description

Monocyte-Neutrophil Elastase Inhibitor, Human is a specific, high-purity biochemical inhibitor designed to target and neutralize human neutrophil elastase (HNE) and related serine proteases. This compound is critical for research and development in inflammatory and autoimmune disease pathways, where uncontrolled elastase activity contributes to tissue degradation. It is an essential tool for pharmaceutical R&D, academic research, and diagnostic assay development focused on pulmonary diseases, rheumatoid arthritis, and other neutrophil-mediated conditions.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active agent in the discovery and validation of novel anti-inflammatory therapeutics targeting neutrophil elastase.
• Biochemical Assay Development: Serves as a key inhibitor in enzymatic assays to study elastase kinetics, screen for other inhibitors, and develop diagnostic tests.
• Academic & Mechanistic Studies: Employed in cell-based and in vitro models to elucidate the role of neutrophil elastase in inflammatory cascades, tissue remodeling, and disease progression.
• Pulmonary Disease Research: Critical for investigating conditions like chronic obstructive pulmonary disease (COPD), cystic fibrosis, and acute respiratory distress syndrome (ARDS).
• Autoimmune & Inflammatory Disease Models: Applied in research on rheumatoid arthritis, vasculitis, and other conditions where neutrophil infiltration and protease release are pathogenic.
• Quality Control & Standardization: Used as a calibrated standard in the quality control of related biopharmaceutical products and assay kits.

Basic Information

Product Name	Monocyte-Neutrophil Elastase Inhibitor, Human
CAS No.	147416-07-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Human Neutrophil Elastase Inhibitor; HNE Inhibitor; Elastase Inhibitor, Human; Serine Protease Inhibitor (Neutrophil); Leukocyte Elastase Inhibitor; PMN Elastase Inhibitor; NE Inhibitor; 147416-07-7
EINECS	Contact for details

Quality Control

Our Monocyte-Neutrophil Elastase Inhibitor, Human is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including purity assay by HPLC, identity confirmation, and biological activity verification to ensure consistent performance and reliability for critical research applications. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Biological Activity (IC50)	Specified per batch
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.