Description

Ac-Tyr-Val-Ala-Asp(Otbu)-Aldehyde-Dimeral Acetal is a synthetic, protected peptide aldehyde derivative, a critical building block in advanced biochemical research and pharmaceutical development. This compound serves as a potent and selective inhibitor for studying the mechanisms of proteases, particularly caspases, which are central to programmed cell death (apoptosis). It is an essential tool for researchers and developers in drug discovery, proteomics, and the development of novel therapeutic agents targeting cancer, neurodegenerative diseases, and inflammatory conditions.

Application

• Protease Inhibitor Research: Key substrate for investigating the activity and specificity of caspase enzymes and other aspartic proteases.
• Apoptosis Pathway Studies: Used to modulate apoptotic signaling cascades in cellular and biochemical assays to understand disease mechanisms.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of more complex peptide-based drug candidates and diagnostic probes.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) platforms to identify and validate new therapeutic compounds.
• Academic & Industrial R&D: Fundamental reagent for universities, research institutes, and biotech companies focused on life sciences.

Basic Information

Item	Detail
Product Name	Ac-Tyr-Val-Ala-Asp(Otbu)-Aldehyde-Dimethyl Acetal
CAS No.	147395-39-9
Molecular Formula	C30H46N4O10
Molecular Weight	622.71 g/mol
Synonyms	Ac-YVAD-CH(OCH3)2; Acetyl-Tyr-Val-Ala-Asp-aldehyde dimethyl acetal; Caspase-1 Inhibitor, Ac-YVAD-CHO (protected); Ac-YVAD-Aldehyde Dimethyl Acetal; N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-L-α-aspartyl aldehyde dimethyl acetal; tert-Butyl L-α-(1,1-dimethoxy-2-oxoethyl)-N-[N-[N-acetyl-L-tyrosyl-L-valyl]L-alanyl]L-aspartate; L-Aspartic acid, N-[N-[N-acetyl-L-tyrosyl-L-valyl]-L-alanyl]-, 1-(1,1-dimethoxyethyl) 4-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Every batch of our peptide derivatives is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting research reproducibility. A Certificate of Analysis (COA) detailing specifications such as purity (by HPLC), chiral integrity, and moisture content is supplied with each order. Our production adheres to standards suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.