Description

Kynostatin CAS NO 147384-69-8 is a potent and specific inhibitor of calpain, a family of calcium-dependent cysteine proteases. This compound is a critical research tool for studying the role of calpain in cellular processes such as apoptosis, signal transduction, and cytoskeletal remodeling. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies involved in neuroscience, cardiology, and muscular dystrophy research to elucidate disease mechanisms and validate novel therapeutic targets.

Application

• Biomedical Research: A key reagent for investigating calpain-mediated pathways in models of neurodegenerative diseases (e.g., Alzheimer's, Parkinson's), ischemic injury, and muscular disorders.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening (HTS) assays to identify and characterize new calpain inhibitors.
• Cellular Biology Studies: Employed to inhibit calpain activity in cell culture experiments to study its effects on cell migration, proliferation, and death.
• Enzymology: Serves as a specific inhibitor in enzymatic assays to determine calpain activity and specificity amidst other protease families.
• Signal Transduction Research: Used to dissect the role of calpain in key signaling cascades involving proteins like PKC, talin, and spectrin.

Basic Information

Product Name	Kynostatin
CAS No.	147384-69-8
Molecular Formula	C₂₀H₃₈N₄O₄
Molecular Weight	398.54 g/mol
Synonyms	Kynostatin; (2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(Aminosulfonyl)amino]acetyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-N-[(1S)-3-cyclohexyl-1-[[(1S)-2-hydroxy-1-phenylethyl]amino]-1-oxopropan-2-yl]pentanediamide; Calpain Inhibitor I; MDL 28170; Z-Val-Phe-CHO; Z-VF-CHO; N-Acetyl-Leu-Leu-Nle-CHO; ALLN
EINECS	Contact for details

Quality Control

Our Kynostatin is produced and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure identity, potency, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing the exact specifications and test results for your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.