Description

Kynostatin 272 is a potent and selective inhibitor of the cysteine protease calpain, specifically targeting calpain I (μ-calpain). This compound is a critical research tool for studying the role of calpain-mediated proteolysis in cellular processes such as signal transduction, apoptosis, and neurodegeneration. It is essential for researchers in pharmaceutical development, neuroscience, and cell biology who require high-purity biochemical reagents for mechanistic studies and target validation.

Application

• Biochemical Research: A key tool compound for investigating the physiological and pathological functions of calpain enzymes in vitro and in cellular models.
• Neuroscience Studies: Used to probe the involvement of calpain in neuronal death, synaptic plasticity, and conditions like stroke, traumatic brain injury, and Alzheimer's disease.
• Pharmaceutical Screening: Serves as a reference standard and positive control in high-throughput screening assays for the discovery of novel calpain inhibitors.
• Cardiovascular Research: Applied in studies of myocardial ischemia-reperfusion injury and other heart conditions where calpain activation plays a role.
• Muscle Biology: Utilized to understand calpain's function in muscle protein turnover, atrophy, and muscular dystrophy.
• Apoptosis Signaling Pathways: Helps delineate the caspase-independent cell death pathways mediated by calpain.

Basic Information

Product Name	Kynostatin 272
CAS No.	147318-81-8
Molecular Formula	C20H30N4O4
Molecular Weight	390.48 g/mol
Synonyms	Kynostatin 272; (2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-N-[(1S)-3-[(diaminomethylidene)amino]-1-[(1H-indol-3-yl)methyl]-3-oxopropyl]pentanediamide; Calpain Inhibitor I; MDL 28170; Z-Val-Phe-CHO; N-Acetyl-Leu-Leu-Nle-CHO
EINECS	Contact for details

Quality Control

Our Kynostatin 272 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.