Description

Pepticinnamin E is a potent and selective inhibitor of the enzyme protein farnesyltransferase (FTase), a key target in cancer research. This compound is crucial for studying signal transduction pathways and the role of Ras oncoproteins in cell proliferation and tumorigenesis. It is an essential research-grade biochemical for pharmaceutical R&D, academic institutions, and biotechnology companies focused on oncology and molecular biology.

Application

• Oncology Research: Used as a key pharmacological tool to investigate the farnesylation-dependent activation of Ras proteins and their role in cancer development.
• Signal Transduction Studies: Employed to selectively inhibit FTase, enabling the study of downstream effects on cell growth, differentiation, and apoptosis pathways.
• Drug Discovery & Development: Serves as a reference compound and lead structure in the design and screening of novel anti-cancer therapeutics targeting the FTase enzyme.
• Biochemical Assay Development: Utilized as a standard inhibitor in enzymatic assays to validate FTase activity and screen for new inhibitor candidates.
• Academic & Pharmaceutical R&D: A critical reagent for basic research in molecular biology and for target validation studies within pre-clinical drug development pipelines.

Basic Information

Product Name	Pepticinnamin E
CAS No.	147317-36-0
Molecular Formula	C34H44N4O6S
Molecular Weight	636.80 g/mol
Synonyms	N-[2(S)-[2(R)-Amino-3-mercaptopropyl]amino-1(S)-methyl-2-oxoethyl]-L-leucyl-N-[1(S)-(cyclohexylmethyl)-2(R)-hydroxy-3-methylbutyl]-L-methioninamide; FTase Inhibitor I; Protein Farnesyltransferase Inhibitor I; Pepticinnamin E (FTI I); L-739,750
EINECS	Contact for details

Quality Control

Our Pepticinnamin E is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to high-purity standards suitable for pharmaceutical research, with typical purity levels exceeding 95% by HPLC. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the primary container sealed in a secondary, moisture-proof barrier. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity (FTase Assay)	IC50 provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.