Description

Kcna1 Channel CAS NO 147173-20-4 is a high-purity, biologically active compound that functions as a selective and potent inhibitor of the voltage-gated potassium channel Kv1.1, encoded by the KCNA1 gene. This specificity makes it an invaluable research tool for elucidating the role of this channel subtype in neuronal excitability, synaptic transmission, and associated neurological disorders. It is essential for pharmaceutical R&D, academic neuroscience research, and the development of targeted neurological therapeutics.

Application

• Neuroscience Research: Fundamental studies on potassium channel physiology, neuronal firing patterns, and action potential propagation.
• Drug Discovery & Pharmacology: High-throughput screening (HTS) and lead optimization for novel CNS-targeting drugs, including anticonvulsants and neuroprotectants.
• Disease Mechanism Investigation: Research into channelopathies such as episodic ataxia type 1 (EA1) and certain forms of epilepsy linked to KCNA1 dysfunction.
• Electrophysiology: A key reference compound for patch-clamp experiments to characterize Kv1.1 channel currents and pharmacology.
• Biochemical Assay Development: Used as a control inhibitor in binding assays and functional cellular assays.
• Academic & Institutional Labs: A critical reagent for graduate and post-doctoral research projects focused on ion channel biology.

Basic Information

Product Name	Kcna1 Channel
CAS No.	147173-20-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Kv1.1 Channel Blocker; KCNA1 Inhibitor; Potassium Voltage-Gated Channel Subfamily A Member 1 Blocker; Shaker-Related Potassium Channel Blocker; Dendrotoxin K (DTX-K) analogue; α-Dendrotoxin-sensitive potassium channel inhibitor
EINECS	Contact for details

Quality Control

Every batch of our Kcna1 Channel inhibitor is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistent biological activity. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing purity, potency, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. This material is intended for research use only in a laboratory setting.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Biological Activity (IC50)	Reported with COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.