Description

3,4-Piperidinediol,5-Fluoro-2-Methyl-,[2R-(2Alpha,3Beta,4Alpha,5Alpha)]-(9Ci) is a high-purity, stereochemically defined piperidine derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in its unique fluorinated and multi-hydroxylated structure, which is essential for imparting specific biological activity and metabolic stability to drug candidates. This advanced intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in the areas of central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Neurological Drug Research: Used as a core scaffold for synthesizing potential compounds targeting neurological disorders.
• Enzyme Inhibitor Development: The fluorinated piperidine structure is valuable for creating potent and selective enzyme inhibitors.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug-like properties.
• Process Chemistry: Used in route scouting and scale-up for the commercial manufacturing of complex drug molecules.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs supporting outsourced drug discovery and development programs.

Basic Information

Product Name	3,4-Piperidinediol,5-Fluoro-2-Methyl-,[2R-(2Alpha,3Beta,4Alpha,5Alpha)]-(9Ci)
CAS No.	147006-75-5
Molecular Formula	C6H10FNO2
Molecular Weight	147.15 g/mol
Synonyms	(2R,3S,4R,5R)-5-Fluoro-2-methylpiperidine-3,4-diol; 5-Fluoro-2-methyl-3,4-piperidinediol (2R,3S,4R,5R)-; (2R,3S,4R,5R)-5-Fluoro-2-methyl-3,4-piperidinediol; 5-Fluoro-2-methyl-(2R,3S,4R,5R)-piperidine-3,4-diol; 147006-75-5; Fluorinated Piperidinediol Derivative; Chiral Fluoropiperidinol
EINECS	Contact for details

Quality Control

Our 3,4-Piperidinediol,5-Fluoro-2-Methyl-,[2R-(2Alpha,3Beta,4Alpha,5Alpha)]-(9Ci) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All products undergo rigorous analytical testing, including chiral purity verification by HPLC, to meet stringent customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.