Description

3-Bromo-2-Fluoro-5-Chlorotoluene is a high-purity halogenated toluene derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an exceptionally valuable intermediate for constructing complex molecules with precise electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the halogen atoms contribute to bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for specialty monomers and ligands used in catalysis and the development of advanced polymeric materials.
• Liquid Crystal & OLED Development: Employed in the synthesis of fluorinated and halogenated aromatic cores for electronic materials requiring specific dipole moments and intermolecular interactions.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions due to the presence of the bromo substituent, enabling efficient carbon-carbon bond formation.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the fine chemical market.

Basic Information

Product Name	3-Bromo-2-Fluoro-5-Chlorotoluene
CAS No.	146948-69-8
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-Bromo-2-fluoro-5-chloro-4-methylbenzene; 2-Fluoro-3-bromo-5-chlorotoluene; 5-Chloro-3-bromo-2-fluorotoluene; Toluene, 3-bromo-2-fluoro-5-chloro-; 4-Methyl-2-fluoro-3-bromo-1-chlorobenzene; 3-Bromo-2-fluoro-5-chloro-1-methylbenzene; Benzene, 1-bromo-2-fluoro-5-chloro-4-methyl-
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-2-Fluoro-5-Chlorotoluene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the exacting standards required for research and scale-up applications. A detailed Certificate of Analysis (COA), including purity assay and impurity profile by GC/HPLC, is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.