Description

(R,S)-MCPG is a potent and selective group II metabotropic glutamate receptor (mGluR) antagonist. This compound is a critical research tool for investigating the role of glutamate signaling in neurological pathways. It is primarily utilized by pharmaceutical researchers and neuroscientists in academic, biotechnology, and industrial R&D settings for studying synaptic plasticity, neuroprotection, and the mechanisms underlying various CNS disorders.

Application

• Neuroscience Research: A key pharmacological agent for studying the function of group II mGluRs (mGluR2 and mGluR3) in the central nervous system.
• Drug Discovery & Development: Used in high-throughput screening and target validation assays to identify and characterize novel therapeutics for neurological and psychiatric conditions.
• Mechanistic Studies: Employed to elucidate the role of glutamate in synaptic transmission, neuronal excitability, and long-term potentiation/depression (LTP/LTD).
• Preclinical Models: Applied in animal models to investigate potential treatments for anxiety, schizophrenia, Parkinson's disease, and chronic pain.
• Biochemical Assays: Serves as a reference standard in receptor binding studies and functional cellular assays to determine agonist/antagonist activity.

Basic Information

Product Name	(R,S)-MCPG
CAS No.	146669-29-6
Molecular Formula	C10H11NO5
Molecular Weight	225.20 g/mol
Synonyms	(RS)-α-Methyl-4-carboxyphenylglycine; (R,S)-MCPG; DL-α-Methyl-4-carboxyphenylglycine; (RS)-MCPG; α-MCPG; mGluR II antagonist; Group II metabotropic glutamate receptor antagonist; (RS)-α-Methyl-4-carboxy-phenylglycine
EINECS	Contact for details

Quality Control

Our (R,S)-MCPG is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	<20 ppm
Residue on Ignition	<0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.