Description

Benzene, 1-(2,2-Dimethyl-1-Methylenepropyl)-3-Fluoro- is a specialized fluorinated aromatic compound with a unique neopentylidene substituent, offering a valuable combination of steric bulk and electronic influence for advanced chemical synthesis. This compound serves as a critical high-purity building block in the development of complex molecules, particularly in pharmaceutical and agrochemical research where precise structural modification is required. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical intermediate, and material science sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the fluorine atom and bulky group can improve target binding and environmental persistence.
• Ligand and Catalyst Development: Serves as a sophisticated backbone for creating sterically demanding ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of specialty monomers for advanced polymers, liquid crystals, or organic electronic materials, leveraging its unique structural motifs.
• Chemical Biology Probes: Acts as a building block for fluorescent tags, photoaffinity labels, or other molecular probes used in biochemical and diagnostic research.

Basic Information

Product Name	Benzene, 1-(2,2-Dimethyl-1-Methylenepropyl)-3-Fluoro-
CAS No.	146558-44-3
Molecular Formula	C12H15F
Molecular Weight	178.25 g/mol
Synonyms	3-Fluoro-α-neopentylstyrene; 1-(3-Fluorophenyl)-3,3-dimethylbut-1-ene; 1-Fluoro-3-(3,3-dimethylbut-1-en-1-yl)benzene; (3-Fluorophenyl)neopentylidene methane; 3-Fluoro-α-neopentylstyrol; 1-(2,2-Dimethyl-1-methylenepropyl)-3-fluorobenzene; 3-Fluoro-α-(2,2-dimethylpropylidene)toluene
EINECS	Contact for details

Quality Control

Our Benzene, 1-(2,2-Dimethyl-1-Methylenepropyl)-3-Fluoro- is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Quality is verified using advanced analytical techniques including GC, HPLC, and NMR spectroscopy.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.