Description

Tyrphostin Ag 1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine kinase. This compound is a critical research tool for elucidating signal transduction pathways and studying cellular processes such as proliferation, migration, and angiogenesis. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology research, cardiovascular studies, and the development of targeted cancer therapies. The high-purity material ensures reliable and reproducible experimental results.

Application

• Biochemical Research: Used as a selective PDGFR inhibitor to study tyrosine kinase signaling pathways and their role in cell growth and differentiation.
• Oncology & Cancer Research: Investigated for its potential to inhibit tumor growth and angiogenesis driven by PDGFR signaling in various cancer models.
• Cardiovascular Research: Applied in studies exploring the role of PDGFR in atherosclerosis, vascular remodeling, and restenosis.
• Cell Culture & In Vitro Studies: Employed to modulate PDGFR activity in cell-based assays to understand its function in specific cellular contexts.
• Drug Discovery & Development: Serves as a reference compound or lead structure in the screening and development of novel tyrosine kinase inhibitors.
• Signal Transduction Analysis: A key reagent for dissecting complex intracellular signaling networks involving receptor tyrosine kinases.

Basic Information

Product Name	Tyrphostin Ag 1296
CAS No.	146535-11-7
Molecular Formula	C₁₇H₁₄N₂O₃
Molecular Weight	294.31 g/mol
Synonyms	AG 1296; Tyrphostin AG 1296; 6,7-Dimethoxy-2-phenylquinoxaline; AG-1296; PDGFR Tyrosine Kinase Inhibitor AG1296; 6,7-Dimethoxy-2-phenylquinoxaline; NSC 354731; Quinoxaline, 6,7-dimethoxy-2-phenyl-
EINECS	Contact for details

Quality Control

Our Tyrphostin Ag 1296 is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.