Description

Terpestacin CAS NO 146436-22-8 is a potent and specific fungal metabolite belonging to the class of sesterterpenoids. This compound is of significant interest in biochemical and pharmacological research due to its unique mechanism of action as a selective inhibitor of angiogenesis and tumor cell invasion. It serves as a critical reference standard and a valuable tool compound for researchers in the fields of oncology, vascular biology, and natural product chemistry, enabling the study of cellular signaling pathways and the development of novel therapeutic strategies.

Application

• Biomedical Research: Used as a reference standard and a potent tool compound in angiogenesis and cancer metastasis studies.
• Pharmacological Screening: Serves as a lead compound or a positive control in high-throughput screening assays for anti-cancer and anti-angiogenic drug discovery.
• Mechanistic Studies: Employed to investigate specific cellular pathways related to cell motility, invasion, and endothelial cell function.
• Natural Product Chemistry: Acts as a benchmark for the isolation, identification, and synthesis of complex sesterterpenoid structures.
• Academic & Institutional Research: Essential for universities and research institutes focusing on cell biology, oncology, and chemical biology.

Basic Information

Product Name	Terpestacin
CAS No.	146436-22-8
Molecular Formula	C25H34O5
Molecular Weight	414.53 g/mol
Synonyms	Terpestacin; FR901459; (-)-Terpestacin; (3S,4aR,5R,6R,8aR)-5,6-Dihydroxy-3-[(1E,3E,5E)-6-hydroxy-6-methylhepta-1,3,5-trien-1-yl]decahydro-4a-methylnaphthalene-1-carboxylic acid; FR 901459; Angiogenesis Inhibitor FR901459
EINECS	Contact for details

Quality Control

Our Terpestacin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.