Description

Flavopiridol is a synthetic flavonoid and a potent, broad-spectrum cyclin-dependent kinase (CDK) inhibitor. This compound is a critical research tool for studying cell cycle regulation, apoptosis, and signal transduction pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology and cell biology research. Flavopiridol CAS NO 146426-40-6 represents a high-purity reference standard for investigative and developmental applications.

Application

• Oncology Research: As a pan-CDK inhibitor, it is extensively used in preclinical studies to investigate its effects on cancer cell proliferation and as a potential chemotherapeutic agent.
• Biochemical Assay Standard: Serves as a key reference compound in high-throughput screening (HTS) and enzymatic assays targeting CDK1, CDK2, CDK4, CDK6, and CDK9.
• Apoptosis & Cell Cycle Studies: A vital tool for researchers exploring mechanisms of programmed cell death and cell cycle arrest in various disease models.
• Pharmaceutical Development: Used in the synthesis and analytical method development for novel therapeutic agents targeting kinase pathways.
• Academic Research: Employed in university and institutional labs for fundamental research in molecular biology and pharmacology.

Basic Information

Product Name	Flavopiridol
CAS No.	146426-40-6
Molecular Formula	C₂₁H₂₀ClNO₅
Molecular Weight	401.84 g/mol
Synonyms	Alvocidib; HMR 1275; L86-8275; NSC 649890; Flavopiridol hydrochloride; 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one
EINECS	Contact for details

Quality Control

Our Flavopiridol is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines suitable for research-grade materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.