Description

Desmethylrocaglamide is a bioactive natural product derivative belonging to the rocaglamide class of compounds, known for its potent and specific biological activity. This compound is of significant interest in pharmaceutical research and development due to its role as a selective inhibitor of eukaryotic translation initiation. It is primarily utilized by researchers in the life sciences sector for target validation, mechanistic studies, and as a lead compound in drug discovery programs, particularly in oncology and virology.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and a potent tool compound for studying protein synthesis inhibition and cellular stress pathways.
• Oncology Research: Investigated for its anti-proliferative and pro-apoptotic effects against various cancer cell lines, aiding in the discovery of novel chemotherapeutic agents.
• Virology Studies: Used in research to explore its potential antiviral properties by inhibiting the replication of certain viruses.
• Biochemical Assay Development: Employed as a key component in high-throughput screening (HTS) assays to identify new modulators of translation initiation.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in molecular biology and cell signaling.
• Pre-clinical Drug Discovery: Acts as a structural template for medicinal chemistry efforts aimed at developing analogs with improved pharmacokinetic properties.

Basic Information

Product Name	Desmethylrocaglamide
CAS No.	146408-78-8
Molecular Formula	C28H29NO8
Molecular Weight	507.54 g/mol
Synonyms	1H-Cyclopenta[b]benzofuran-5a(1H)-carboxylic acid, 1-(4-aminophenyl)-1,2,3,4,4a,5,6,10b-octahydro-8,9-dimethoxy-2-(1-methylethenyl)-6-oxo-, methyl ester, (1R,2R,3aS,4aR,5S,10bS)-; (-)-Desmethylrocaglamide; Rocaglamide, desmethyl-; 1-Desmethylrocaglamide; Compound 1b (Rocaglamide derivative); AGM-1470 analog; Translation inhibitor AGM-1470 derivative.
EINECS	Contact for details

Quality Control

Our Desmethylrocaglamide is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to confirm identity and purity. A Certificate of Analysis (COA) detailing all relevant specifications is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a desiccated environment to maintain product integrity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.