Description

Zaragozic Acid B CAS NO 146389-61-9 is a potent and selective inhibitor of squalene synthase, a key enzyme in the cholesterol biosynthesis pathway. This compound is a critical tool for biochemical research, enabling the study of sterol metabolism and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on metabolic disease research and drug discovery.

Application

• Biochemical Research: A standard tool for studying the mevalonate pathway and isoprenoid biosynthesis in vitro and in cell-based assays.
• Enzyme Inhibition Studies: Used to specifically inhibit squalene synthase activity to elucidate its role in cellular processes and disease models.
• Pharmaceutical Development: Serves as a lead compound or reference standard in the discovery of new cholesterol-lowering agents and antifungal drugs.
• Metabolic Pathway Analysis: Employed to investigate the downstream effects of blocking sterol synthesis on cell signaling, proliferation, and homeostasis.
• Academic & Institutional Research: Essential for fundamental research in biochemistry, cell biology, and pharmacology related to lipid metabolism.

Basic Information

Product Name	Zaragozic Acid B
CAS No.	146389-61-9
Molecular Formula	C30H42O8
Molecular Weight	530.65 g/mol
Synonyms	Zaragozic Acid B; Squalestatin B; Squalestatin 2; Zaragozic Acid B (Squalestatin 2); L-669,262; (1R,2R,5S,6S,7S,8S,9S)-2,6,8-Trihydroxy-9-[(1S)-1-hydroxy-2-methylpropyl]-1,5,7-tris(2-methylpropyl)bicyclo[3.3.1]nonane-3,3,4,4-tetracarboxylic acid; 146389-61-9
EINECS	Contact for details

Quality Control

Our Zaragozic Acid B is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.