Description

(Rs)-3,5-DHPG is a high-purity, non-natural amino acid derivative and a potent, selective group II metabotropic glutamate receptor (mGluR) agonist. This compound is a critical research-grade chemical for neuroscience and pharmacological studies, enabling the investigation of glutamatergic signaling pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neurological disorders and drug discovery.

Application

• Neuroscience Research: A key pharmacological tool for studying the function and modulation of group II mGluRs (mGluR2 and mGluR3) in synaptic transmission and plasticity.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the design of novel therapeutics targeting neurological conditions such as anxiety, schizophrenia, and Parkinson's disease.
• Biochemical Assays: Used in high-throughput screening (HTS) and in vitro receptor binding/functional assays to identify and characterize new drug candidates.
• Academic & Clinical Research: Facilitates fundamental research into glutamate receptor biology, neuronal excitability, and the pathophysiology of CNS disorders.
• Preclinical Studies: Employed in animal models to evaluate the therapeutic potential and mechanisms of action of mGluR-targeting agents.

Basic Information

Product Name	(Rs)-3,5-DHPG
CAS No.	146255-66-5
Molecular Formula	C9H11NO5
Molecular Weight	213.19 g/mol
Synonyms	(RS)-3,5-Dihydroxyphenylglycine; (RS)-3,5-DHPG; DL-3,5-DHPG; (±)-3,5-Dihydroxyphenylglycine; 2-Amino-2-(3,5-dihydroxyphenyl)acetic acid; Group II mGluR agonist (RS)-form; mGlu2/3 receptor agonist (racemic)
EINECS	Contact for details

Quality Control

Our (Rs)-3,5-DHPG is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) containing lot-specific data is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.