Description

Hydroxypioglitazone CAS NO 146062-44-4 is a key pharmaceutical intermediate and active metabolite of the thiazolidinedione class, primarily associated with the drug pioglitazone. This compound is of significant value in research and development for its role in studying metabolic pathways and drug efficacy. It is essential for pharmaceutical manufacturers, research institutions, and analytical laboratories focused on diabetes treatment, drug metabolism studies, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical synthesis component for the production of pioglitazone and related antidiabetic medications.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies, pharmacokinetics, and drug metabolism research.
• Biochemical Research: Employed in studies investigating peroxisome proliferator-activated receptor gamma (PPARγ) activation and insulin sensitization mechanisms.
• Quality Control & Assurance: Serves as a certified reference material (CRM) for HPLC, LC-MS, and other analytical methods in pharmaceutical QC labs.
• Academic & Clinical Research: Utilized in university and institutional research projects exploring new therapeutic applications for metabolic disorders.

Basic Information

Product Name	Hydroxypioglitazone
CAS No.	146062-44-4
Molecular Formula	C19H20N2O3S
Molecular Weight	356.44 g/mol
Synonyms	5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; Hydroxy Pioglitazone; Pioglitazone Hydroxy Metabolite; Pioglitazone Metabolite M-IV; KRP-101; U-72107A; 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
EINECS	Contact for details

Quality Control

Our Hydroxypioglitazone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.