Description

2,6-Dimethoxybenzene-1-Sulfonyl Chloride is a specialized aromatic sulfonyl chloride derivative, serving as a key electrophilic reagent and versatile synthetic building block. Its primary value lies in enabling the introduction of the 2,6-dimethoxybenzenesulfonyl moiety, a functional group of significant interest in advanced organic synthesis and pharmaceutical development. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality building blocks for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly for introducing sulfonamide groups into complex molecular architectures.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the dimethoxy-substituted sulfonyl group can impart specific biological activity.
• Peptide Chemistry & Bioconjugation: Acts as a sulfonylation agent for modifying amino acids, peptides, or proteins to alter their properties or create targeted conjugates.
• Material Science Research: Employed in the synthesis of functional polymers, dyes, and advanced organic materials that require specific sulfonated aromatic units.
• Chemical Derivatization Agent: Useful in analytical chemistry for derivatizing compounds to enhance detection or separation in techniques like HPLC or LC-MS.
• Cross-coupling & Catalysis Ligand Synthesis: Serves as a precursor for synthesizing specialized ligands used in transition metal-catalyzed reactions.

Basic Information

Product Name	2,6-Dimethoxybenzene-1-Sulfonyl Chloride
CAS No.	145980-89-8
Molecular Formula	C8H9ClO4S
Molecular Weight	236.67 g/mol
Synonyms	2,6-Dimethoxybenzenesulfonyl Chloride; 1,3-Dimethoxy-2-sulfonylchloridobenzene; 2,6-Dimethoxybenzene Sulfonyl Chloride; 2,6-Dimethoxybenzenesulphonyl Chloride; 2,6-Dimethoxyphenylsulfonyl Chloride; 2,6-Dimethoxy-1-sulfonyl Chloride Benzene; 2,6-Dimethoxybenzene-1-sulfonylchloride
EINECS	Contact for details

Quality Control

Our production of 2,6-Dimethoxybenzene-1-Sulfonyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assay, identity confirmation by FT-IR and NMR spectroscopy, and control of key impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support cGMP-compliant manufacturing for pharmaceutical applications and can tailor quality specifications to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.