Description

2-(Difluoromethoxy)-5-Nitrobenzaldehyde is a specialized aromatic aldehyde building block featuring both difluoromethoxy and nitro substituents, which impart unique electronic and steric properties. This compound is valued for its role as a critical intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is essential for chemists and manufacturers in the fine chemical, pharmaceutical, and crop protection industries who require high-purity, functionalized intermediates for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic areas where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the nitro and aldehyde functionalities allow for further derivatization into active compounds.
• Material Science Research: Serves as a building block for creating advanced organic materials, such as liquid crystals, polymers, and organic electronic components, due to its distinct molecular architecture.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new organic reactions, catalytic processes, and as a standard for analytical method development.
• Dye and Pigment Intermediate: Can be utilized in the synthesis of specialized dyes and pigments where the nitro group contributes to color properties and the aldehyde allows for condensation reactions.

Basic Information

Product Name	2-(Difluoromethoxy)-5-Nitrobenzaldehyde
CAS No.	145742-63-8
Molecular Formula	C8H5F2NO4
Molecular Weight	217.13 g/mol
Synonyms	5-Nitro-2-(difluoromethoxy)benzaldehyde; 2-(Difluoromethoxy)-5-nitrobenzaldehyde; Benzaldehyde, 2-(difluoromethoxy)-5-nitro-; α,α-Difluoro-5-nitro-o-anisaldehyde
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-5-Nitrobenzaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to pale brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.