Description

2-(2,2,2-Trifluoroethoxy)Benzaldehyde is a high-purity fluorinated aromatic aldehyde building block, distinguished by its trifluoroethoxy substituent which imparts unique electronic and lipophilic properties. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its structure enables the fine-tuning of biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoroethoxy group enhances compound penetration and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, improving charge transport and thermal properties.
• Organic Synthesis & Catalysis: Employed as a versatile electrophile in cross-coupling reactions, nucleophilic additions, and as a ligand precursor in organometallic chemistry.
• Fluorinated Polymer Research: Acts as a monomer or modifier in the research and development of specialty polymers with enhanced chemical resistance and low surface energy.
• Dye & Pigment Intermediate: Utilized in the synthesis of complex fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	2-(2,2,2-Trifluoroethoxy)Benzaldehyde
CAS No.	145742-43-4
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	2-(2,2,2-Trifluoroethoxy)benzaldehyde; o-(Trifluoroethoxy)benzaldehyde; Benzaldehyde, 2-(2,2,2-trifluoroethoxy)-; 2-Trifluoroethoxybenzaldehyde; 1-(Trifluoroethoxy)-2-formylbenzene; 2-Formylphenyl 2,2,2-trifluoroethyl ether; α,α,α-Trifluoro-o-tolyl aldehyde ether
EINECS	Contact for details

Quality Control

Every batch of 2-(2,2,2-Trifluoroethoxy)Benzaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC/HPLC is supplied with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.