Description

4,5-Difluoro-2-Methoxybenzaldehyde is a high-purity fluorinated aromatic aldehyde building block of significant importance in advanced organic synthesis. Its value lies in its unique substitution pattern, which makes it a versatile precursor for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily needed by R&D chemists and process development scientists working on the synthesis of active pharmaceutical ingredients (APIs), liquid crystal materials, and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoro-methoxy motif enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a core building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: The aldehyde group is amenable to further functionalization via reactions like Suzuki, Heck, or reductive amination.
• Chemical Research & Development: A valuable reagent for academic and industrial research exploring new fluorinated chemical entities.

Basic Information

Product Name	4,5-Difluoro-2-Methoxybenzaldehyde
CAS No.	145742-34-3
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	2-Methoxy-4,5-difluorobenzaldehyde; 4,5-Difluoro-2-methoxybenzaldehyde; 4,5-Difluoro-o-anisaldehyde; 2-Methoxy-4,5-difluorobenzenecarboxaldehyde; 4,5-Difluoro-2-methoxybenzenecarbaldehyde; 145742-34-3; 4,5-Difluoro-2-methoxy-benzaldehyde
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Methoxybenzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.