Description

Calpain Inhibitor Xi is a potent, cell-permeable inhibitor of the calcium-dependent cysteine protease enzyme family, calpains. This compound is critical for researchers investigating the role of calpain-mediated proteolysis in cellular processes such as apoptosis, signal transduction, and cytoskeletal remodeling. It is an essential biochemical tool for pharmaceutical R&D, academic research, and biotechnology applications focused on neurodegenerative diseases, muscular dystrophy, and ischemia-reperfusion injury.

Application

• Biochemical Research: A key reagent for studying calpain activity and function in in vitro enzyme assays and cell-based studies.
• Neurodegenerative Disease Research: Used to investigate the pathological role of calpain in conditions like Alzheimer's disease, Parkinson's disease, and traumatic brain injury.
• Cardiovascular Research: Applied in models of myocardial infarction and ischemia-reperfusion injury to understand calpain's involvement in cell death.
• Muscle Biology Studies: Essential for research into muscular dystrophies and other disorders involving calpain-3 (CAPN3) dysfunction.
• Pharmaceutical Screening: Serves as a reference compound and positive control in high-throughput screening for novel calpain inhibitors.
• Cell Signaling Pathway Analysis: Utilized to dissect calpain's role in modulating signaling pathways related to cell proliferation, migration, and death.

Basic Information

Product Name	Calpain Inhibitor Xi
CAS No.	145731-49-3
Molecular Formula	C₂₀H₃₀N₄O₄
Molecular Weight	390.48 g/mol
Synonyms	N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal; (S)-N-((S)-1-((S)-4-Methyl-1-((4-fluorophenyl)sulfonyl)pentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-2-methylpropanamide; ALLN; N-Acetyl-Leu-Leu-Norleucinal; Calpain Inhibitor I; MDL 28170; Ac-LLnL-CHO
EINECS	Contact for details

Quality Control

Our Calpain Inhibitor Xi is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity confirmation, identity verification by IR and NMR spectroscopy, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.