Description

Alvimopan is a peripherally acting mu-opioid receptor antagonist (PAMORA) of significant pharmaceutical importance. This compound is specifically designed to accelerate the recovery of gastrointestinal function following bowel resection surgery, addressing a key post-operative complication. It is primarily utilized in hospital and clinical settings for the management of postoperative ileus (POI). Alvimopan CAS NO 145590-44-9 offers a targeted mechanism of action that blocks opioid receptors in the gut without reversing central analgesic effects.

Application

• Postoperative Ileus (POI) Management: The primary and FDA-approved application for accelerating upper and lower gastrointestinal recovery following partial large or small bowel resection surgery with primary anastomosis.
• Hospital Formulation: Used as the active pharmaceutical ingredient (API) in the manufacture of oral capsules administered under hospital supervision.
• Clinical Research: Serves as a reference standard and key material in pharmacological studies investigating opioid-induced bowel dysfunction and gastrointestinal motility.
• Pharmaceutical Development: Employed in the R&D of novel formulations and delivery systems aimed at improving patient outcomes in abdominal and pelvic surgeries.

Basic Information

Product Name	Alvimopan
CAS No.	145590-44-9
Molecular Formula	C25H32N2O4•2H2O
Molecular Weight	460.56 g/mol (Dihydrate)
Synonyms	LY246736; ADL 8-2698; (2S)-2-[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]pentanamide dihydrate; Alvimopan Dihydrate; Entereg (Brand Name)
EINECS	Contact for details

Quality Control

Our Alvimopan is manufactured under strict quality systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. Certificates of Analysis (COA) are provided with each batch, detailing specifications for identity, purity, and impurities. Quality is assured through compliance with current Good Manufacturing Practices (cGMP) and relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	6.0% - 9.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.