Description

8(14)A-Homocalcitriol CAS NO 145459-22-9 is a synthetic analog of calcitriol, the active form of vitamin D3, featuring a modified side chain that alters its biological profile. This compound is of significant interest for advanced research into vitamin D receptor (VDR) signaling pathways and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on endocrinology, oncology, and dermatology.

Application

• Pharmaceutical Research & Development: A key intermediate or reference standard in the synthesis and study of novel vitamin D analogs for potential therapeutic applications.
• Biochemical Research: Used to investigate the structure-activity relationships (SAR) of vitamin D receptor (VDR) ligands and their downstream effects on gene expression.
• Oncology Research: Studied for its potential effects on cell differentiation, proliferation, and apoptosis in various cancer cell models.
• Metabolic Disorder Studies: Applied in research exploring calcium and phosphate homeostasis, bone metabolism, and related endocrine pathways.
• Dermatology Research: Investigated for potential applications in treating skin conditions like psoriasis by modulating keratinocyte growth and differentiation.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in laboratories.

Basic Information

Product Name	8(14)A-Homocalcitriol
CAS No.	145459-22-9
Molecular Formula	C₂₈H₄₄O₃
Molecular Weight	428.65 g/mol
Synonyms	8(14)A-Homo-1α,25-dihydroxyvitamin D3; 1α,25-Dihydroxy-8(14)a-homocholecalciferol; 8(14)A-Homo-1,25-dihydroxycholecalciferol; 8(14)A-Homo-calcitriol; Vitamin D3 analog 8(14)A-Homo; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,25-triol (homologated derivative)
EINECS	Contact for details

Quality Control

Our 8(14)A-Homocalcitriol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store unopened vials at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.