Description

Sodium-Bile Acid Cotransporter CAS NO 145420-23-1 is a high-purity, synthetic organic compound designed for advanced research and development applications. This compound is critical for investigating the function and modulation of the apical sodium-dependent bile acid transporter (ASBT), a key protein in the enterohepatic circulation of bile acids. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and academic institutions focused on developing novel therapeutics for cholestatic liver diseases, hypercholesterolemia, and metabolic disorders.

Application

• Pharmacological Research: Used as a reference standard or tool compound in studies targeting the Apical Sodium-dependent Bile Acid Transporter (ASBT/SLC10A2).
• Drug Discovery & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) precursor in the synthesis of novel ASBT inhibitors.
• Biochemical Assays: Employed in in vitro screening assays to evaluate the potency and selectivity of potential therapeutic agents.
• Mechanistic Studies: Facilitates research into bile acid homeostasis, intestinal absorption, and related metabolic pathways.
• Academic Research: Supports fundamental scientific investigations in universities and research institutes focused on hepatology and gastroenterology.
• Preclinical Development: Used in animal model studies to assess the efficacy and pharmacokinetics of candidate drugs.

Basic Information

Product Name	Sodium-Bile Acid Cotransporter
CAS No.	145420-23-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ASBT Inhibitor; SLC10A2 Inhibitor; Apical Sodium-dependent Bile Acid Transporter Inhibitor; Bile Acid Transporter Inhibitor; 145420-23-1; Sodium/Bile Acid Cotransporter Inhibitor; Ileal Bile Acid Transporter (IBAT) Inhibitor
EINECS	Contact for details

Quality Control

Our Sodium-Bile Acid Cotransporter is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product under inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content	≤ 0.5%
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.