Description

Sphingofungin E is a potent and specific inhibitor of serine palmitoyltransferase (SPT), a key enzyme in the sphingolipid biosynthesis pathway. This targeted mechanism makes it a critical research tool for studying cellular processes related to sphingolipid metabolism, including cell growth, differentiation, and apoptosis. It is primarily utilized by researchers in the life sciences, pharmaceutical development, and biotechnology sectors for biochemical research and as a reference standard.

Application

• Biochemical Research: As a specific inhibitor to study the role of sphingolipids in cellular signaling, membrane biology, and disease mechanisms.
• Pharmaceutical R&D: Used in target validation and screening assays for drug discovery programs focused on metabolic disorders, cancer, and neurodegenerative diseases.
• Cell Biology Studies: Investigation of cell proliferation, apoptosis, and stress responses mediated by sphingolipid pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Enzyme Kinetics: Tool for characterizing the activity and inhibition kinetics of serine palmitoyltransferase (SPT).

Basic Information

Product Name	Sphingofungin E
CAS No.	145401-47-4
Molecular Formula	C21H39NO5
Molecular Weight	385.54 g/mol
Synonyms	Sphingofungin E; Antibiotic L 687,755; L-687,755; (2S,3R,4E,6E,8E,10E)-2-Amino-3-hydroxy-4,6,8,10-tetradecatetraenedioic acid 10,2-lactam; Sphingofungin E (L 687,755); Serine palmitoyltransferase inhibitor
EINECS	Contact for details

Quality Control

Our Sphingofungin E is produced under stringent quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.