Description

Bisindolylmaleimide Xi Hydrochloride is a potent and selective protein kinase C (PKC) inhibitor, specifically targeting the PKC-β isoform. This high-purity biochemical is critical for advanced life science research, enabling precise modulation of PKC-mediated signaling pathways. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of oncology, neuroscience, and cardiovascular disease studies.

Application

• Biochemical Research: A key tool compound for studying the role of Protein Kinase C (PKC) isoforms, particularly PKC-β, in cellular signaling cascades.
• Pharmaceutical Development: Used in high-throughput screening (HTS) and target validation for drug discovery programs focused on PKC-related diseases.
• Oncology Research: Investigated for its potential to inhibit cancer cell proliferation and angiogenesis by blocking PKC-β activity.
• Neuroscientific Studies: Applied in research exploring PKC's role in neuronal function, synaptic plasticity, and neurodegenerative conditions.
• Inflammatory & Metabolic Disease Models: Utilized to dissect PKC pathways involved in diabetes, cardiac hypertrophy, and inflammatory responses.
• Cell Culture & In Vitro Assays: Serves as a critical reagent in dose-response experiments to establish pharmacological profiles.

Basic Information

Product Name	Bisindolylmaleimide Xi Hydrochloride
CAS No.	145333-02-4
Molecular Formula	C24H22ClN3O2
Molecular Weight	419.90 g/mol
Synonyms	Bisindolylmaleimide XI HCl; Ro 32-0432 hydrochloride; 3-[1-[3-(Amidinothio)propyl]-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide hydrochloride; PKCβ Inhibitor; Protein Kinase C Beta Inhibitor; 2,3-Bis(1H-indol-3-yl)-N-[(aminoiminomethyl)thio]propyl]maleimide hydrochloride; Ro-32-0432
EINECS	Contact for details

Quality Control

Our Bisindolylmaleimide Xi Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and potency. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research integrity and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.