Description

Oxycodone-n-Methyl-D3 Hydrochloride is a deuterated isotopologue of the pharmaceutical compound oxycodone, specifically labeled on the N-methyl group. This high-purity reference material is critical for ensuring analytical accuracy and reliability in regulated environments. It is primarily utilized by pharmaceutical research and development laboratories, forensic toxicology units, and analytical chemistry teams for applications requiring precise quantification and method validation.

Application

• Internal Standard for Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable, non-interfering reference for the accurate quantification of oxycodone and its metabolites in complex biological matrices.
• Pharmaceutical R&D and Method Development: Essential for developing, validating, and calibrating sensitive analytical methods in drug discovery and pharmacokinetic studies.
• Forensic and Clinical Toxicology: Used as a certified reference material for the definitive identification and measurement of oxycodone in urine, blood, and plasma samples.
• Metabolite Studies and Drug Metabolism Research: Enables tracking and differentiation of parent drug from metabolites in ADME (Absorption, Distribution, Metabolism, and Excretion) studies.
• Quality Control and Assurance in Manufacturing: Supports impurity profiling and stability testing of oxycodone-based pharmaceutical products.
• Regulatory Compliance and Documentation: Provides traceable standards for audits and submissions to regulatory bodies like the FDA and EMA.

Basic Information

Product Name	Oxycodone-n-Methyl-D3 Hydrochloride
CAS No.	145225-02-1
Molecular Formula	C18H18D3NO4·HCl
Molecular Weight	351.84 g/mol (for free base C18H18D3NO4)
Synonyms	Oxycodone N-Methyl-d3 Hydrochloride; 14-Hydroxydihydrocodeinone-N-methyl-d3 Hydrochloride; (5α)-14-Hydroxy-3-methoxy-17-methyl-4,5-epoxymorphinan-6-one N-methyl-d3 Hydrochloride; Oxycodone-d3 (N-methyl) HCl; Deuterated Oxycodone Hydrochloride; Oxycodone N-CD3 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Oxycodone-n-Methyl-D3 Hydrochloride is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and confirming the absence of interfering impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.