Description

α-Hydroxytriazolam-D4 is a deuterated analog of the primary metabolite of the pharmaceutical compound triazolam. This high-purity, isotopically labeled standard is critical for ensuring accuracy and reliability in advanced analytical workflows. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical and forensic toxicology sectors for applications such as quantitative analysis, method development, and as an internal standard in mass spectrometry.

Application

• As a certified internal standard for the precise quantification of triazolam and its metabolites in biological matrices using LC-MS/MS and GC-MS.
• For use in pharmacokinetic and metabolic studies to track drug disposition and biotransformation pathways.
• In forensic and clinical toxicology laboratories for accurate drug screening and confirmation assays.
• Essential in pharmaceutical research and development for bioanalytical method validation and stability testing.
• Supporting doping control programs in sports to detect the presence of banned substances.
• Used as a critical reference material in regulatory compliance and quality assurance testing for drug manufacturers.

Basic Information

Product Name	α-Hydroxytriazolam-D4
CAS No.	145225-01-0
Molecular Formula	C17H8D4Cl2N4O
Molecular Weight	349.20 g/mol (for deuterated form)
Synonyms	8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-α-ol-d4; 1-Hydroxytriazolam-d4; α-Hydroxytriazolam-d4; Triazolam Metabolite D4; Triazolam α-Hydroxy D4; Deuterated α-Hydroxytriazolam; [1,2,4]Triazolo[4,3-a][1,4]benzodiazepin-α-ol-d4 derivative
EINECS	Contact for details

Quality Control

Every batch of α-Hydroxytriazolam-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for identity, purity, isotopic enrichment, and solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.