Description

4'-Demethylamino-4'-Hydroxy-3'-Epistaurosporine is a chemically modified analog of the potent protein kinase inhibitor staurosporine. This compound matters as a valuable biochemical tool for targeted research in cell signaling pathways, particularly for studying kinase inhibition mechanisms. It is primarily needed by researchers and developers in the pharmaceutical and biotechnology sectors for drug discovery, biochemical assay development, and academic research into oncology and neurology. The product is supplied with a high level of purity to ensure reliable and reproducible experimental results.

Application

• Biochemical Research: Used as a reference standard and inhibitor in kinase assay development and validation.
• Drug Discovery: Serves as a key intermediate or lead compound in the synthesis and screening of novel therapeutic agents targeting specific kinases.
• Cell Biology Studies: Employed to investigate the role of specific protein kinases in cellular processes such as proliferation, apoptosis, and differentiation.
• Academic Research: Utilized in university and institutional labs for fundamental studies in signal transduction and enzyme kinetics.
• Pharmaceutical Development: Acts as a critical reagent in the preclinical research phase for evaluating drug efficacy and mechanism of action.

Basic Information

Product Name	4'-Demethylamino-4'-Hydroxy-3'-Epistaurosporine
CAS No.	145212-39-1
Molecular Formula	C27H25N4O3
Molecular Weight	453.52 g/mol
Synonyms	4'-Demethylamino-4'-hydroxy-3'-epistaurosporine; 3'-Epistaurosporine, 4'-demethylamino-4'-hydroxy-; 4'-Demethylamino-4'-hydroxy-3'-epistaurosporine; Staurosporine analog; Protein kinase C inhibitor analog; K-252a analog; Research compound 145212-39-1
EINECS	Contact for details

Quality Control

Our 4'-Demethylamino-4'-Hydroxy-3'-Epistaurosporine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and impurities is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content	≤ 5.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.