Description

2-[N,n-Bis(Trifluoromethanesulfonyl)Amino]-5-Chloropyridine is a specialized organofluorine building block featuring a highly electron-withdrawing bis(triflyl)amino (NTf2) group. This compound matters for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where it introduces unique physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the chloropyridine and NTf2 groups contribute to biological activity and environmental persistence.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands in coordination chemistry and catalysis, leveraging the strong electron-withdrawing character of the NTf2 group.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as conductive polymers or non-linear optical (NLO) materials, where its structure aids in tuning electronic properties.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl and heteroaryl systems.
• Fluorination Chemistry: Provides a stable source of a protected amine group that can be further functionalized or used to introduce fluorine-containing fragments into target molecules.

Basic Information

Product Name	2-[N,n-Bis(Trifluoromethanesulfonyl)Amino]-5-Chloropyridine
CAS No.	145100-51-2
Molecular Formula	C7H3ClF6N2O4S2
Molecular Weight	392.69 g/mol
Synonyms	5-Chloro-2-[(trifluoromethanesulfonyl)][(trifluoromethyl)sulfonyl]amino]pyridine; 2-(Bis(trifluoromethanesulfonyl)amino)-5-chloropyridine; 5-Chloro-2-(N,N-bis(trifluoromethanesulfonyl)amino)pyridine; NTf2-Protected 5-Chloro-2-aminopyridine; 2-Amino-5-chloropyridine bis(triflate) derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Each batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing lot-specific results are available upon request. We adhere to a quality management system to ensure traceability and consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.