Description

4-Ethynyl-2-Fluoro-1-Methyl-Benzene is a high-purity fluorinated aromatic building block containing a reactive ethynyl group. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, particularly in cross-coupling reactions. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting novel therapeutics.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and pesticides with enhanced efficacy.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An essential substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research exploring the effects of fluorine substitution on molecular properties.

Basic Information

Product Name	4-Ethynyl-2-Fluoro-1-Methyl-Benzene
CAS No.	145069-53-0
Molecular Formula	C9H7F
Molecular Weight	134.15 g/mol
Synonyms	2-Fluoro-4-ethynyl-1-methylbenzene; 1-Ethynyl-4-fluoro-2-methylbenzene; 4-Ethynyl-2-fluorotoluene; 2-Fluoro-4-ethynyltoluene; 2-Methyl-5-fluorophenylacetylene; 5-Fluoro-2-methylphenylacetylene; 4-Fluoro-2-methylphenylacetylene
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-2-Fluoro-1-Methyl-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Recommended long-term storage temperature is 2-8°C. This material is easily oxidized and should be handled under inert conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.