Description

ω-Agatoxin Tk CAS NO 145017-83-0 is a highly specific and potent peptide neurotoxin derived from the venom of the funnel-web spider. This compound is a crucial pharmacological tool for the selective and irreversible blockade of P/Q-type voltage-gated calcium channels (Cav2.1). Its primary value lies in enabling precise neurological research, allowing scientists to dissect the role of these channels in synaptic transmission, neurotransmitter release, and associated disease pathways. This makes it essential for researchers and developers in neuroscience, pharmacology, and the development of novel therapeutic agents for neurological disorders.

Application

• Neuroscience Research: A fundamental tool for studying the function of P/Q-type calcium channels in neuronal excitability and synaptic plasticity.
• Pharmacological Studies: Used to characterize receptor subtypes and investigate calcium channel physiology in in vitro and ex vivo experimental models.
• Drug Discovery & Development: Serves as a reference standard and a key reagent in screening programs for novel calcium channel blockers or modulators.
• Cellular Signaling Pathways: Employed to elucidate the role of Cav2.1 channels in intracellular signaling cascades and their link to disease states.
• Academic & Institutional Research: Critical for university labs and research institutes focused on neurobiology, channelopathies, and pain mechanisms.
• Biochemical Assay Development: Used as a specific inhibitor in the development and validation of high-throughput screening assays.

Basic Information

Product Name	ω-Agatoxin Tk
CAS No.	145017-83-0
Molecular Formula	C184H274N52O53S8
Molecular Weight	~4280.9 g/mol
Synonyms	ω-Agatoxin Tk; Agatoxin Tk; ω-Aga-Tk; P/Q-type calcium channel blocker; Calcium channel toxin ω-Aga-Tk; Funnel-web spider toxin Tk; Cav2.1 channel antagonist; Synthetic ω-Agatoxin Tk
EINECS	Contact for details

Quality Control

Our ω-Agatoxin Tk is produced and handled under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch is subjected to comprehensive analytical characterization, including mass spectrometry (MS) for identity confirmation and high-performance liquid chromatography (HPLC) for purity assessment. Certificates of Analysis (COA) detailing purity, potency, and analytical data are provided with every shipment to guarantee traceability and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, solutions should be aliquoted to avoid repeated freeze-thaw cycles and stored at -80°C. Allow the vial to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity	Verified by functional assay (IC50 provided on COA)
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.