Description

Tyrphostin A48 CAS NO 144978-82-5 is a potent and selective inhibitor of protein tyrosine kinases, specifically targeting the epidermal growth factor receptor (EGFR) pathway. This compound is a critical research tool for studying signal transduction mechanisms involved in cell proliferation, differentiation, and oncogenesis. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for drug discovery and biochemical research.

Application

• Biochemical Research: Used as a selective EGFR tyrosine kinase inhibitor to study intracellular signaling pathways and cellular responses.
• Oncology Research: Investigated for its potential anti-proliferative effects in various cancer cell line studies, particularly those driven by EGFR overexpression.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in the design and screening of novel tyrosine kinase inhibitors.
• Cellular Mechanism Studies: Employed to elucidate the role of tyrosine phosphorylation in processes like cell growth, apoptosis, and migration.
• Enzyme Inhibition Assays: A key reagent in in vitro enzymatic assays to measure and characterize kinase activity and inhibition potency.

Basic Information

Product Name	Tyrphostin A48
CAS No.	144978-82-5
Molecular Formula	C₁₆H₁₂N₂O₃
Molecular Weight	280.28 g/mol
Synonyms	AG 99; Tyrphostin AG 99; 3,5-Di-tert-butyl-4-hydroxybenzylidene-malononitrile; EGFR Tyrosine Kinase Inhibitor AG 99; RG 50810; 2-[(3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene]propanedinitrile; NSC 677459; 4-Hydroxy-3,5-di-tert-butylbenzylidenemalononitrile
EINECS	Contact for details

Quality Control

Our Tyrphostin A48 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.