Description

Cyclophostin CAS NO 144773-26-2 is a specialized organophosphorus compound known for its potent and selective biological activity. This compound is of significant interest in biochemical and pharmacological research due to its mechanism of action as an irreversible inhibitor of specific enzymes. It is primarily utilized by research institutions and pharmaceutical development teams focused on enzymology, neurochemistry, and the development of novel therapeutic agents.

Application

• Enzyme Inhibition Studies: Used as a potent, irreversible inhibitor for investigating the structure and function of specific serine hydrolases and esterases.
• Neurochemical Research: Employed in studies targeting enzymes like neuropathy target esterase (NTE) to model and understand certain neurodegenerative conditions.
• Mechanism-Based Probe Development: Serves as a key scaffold or active site probe in the design of activity-based protein profiling (ABPP) reagents.
• Pharmacological Tool Compound: Utilized in vitro to validate biological targets and pathways relevant to drug discovery programs.
• Biochemical Assay Standard: Acts as a reference standard in assays designed to measure specific enzymatic activities or screen for inhibitors.
• Academic and Industrial R&D: Fundamental research tool in universities and biotech companies for exploratory life science projects.

Basic Information

Product Name	Cyclophostin
CAS No.	144773-26-2
Molecular Formula	C7H10NO5P
Molecular Weight	219.13 g/mol
Synonyms	Cyclophostin; 2-[(1S)-1-[(Dimethoxyphosphinyl)oxy]ethyl]-4-hydroxy-5-methyl-2-cyclohexen-1-one; (1S)-1-[(Dimethoxyphosphinyl)oxy]ethyl]-4-hydroxy-5-methyl-2-cyclohexen-1-one; NTE Inhibitor; Neuropathy target esterase inhibitor; Cyclic enol phosphate inhibitor
EINECS	Contact for details

Quality Control

Our Cyclophostin is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including purity assay and identity confirmation via techniques such as HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container sealed under an inert atmosphere if the material is sensitive to moisture or oxidation. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content	≤ 0.5%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.