Description

Concanamycin G CAS NO 144730-82-5 is a potent and specific macrolide antibiotic belonging to the concanamycin family, known for its high-affinity inhibition of vacuolar-type H+-ATPase (V-ATPase). This precise mechanism of action makes it an indispensable research tool for studying intracellular pH regulation, vesicular trafficking, and autophagy pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cell biology, cancer research, and the development of novel therapeutic agents targeting osteoclast function and neurodegenerative diseases.

Application

• Biochemical Research: A critical tool for investigating the role of V-ATPase in cellular processes such as receptor-mediated endocytosis, lysosomal acidification, and protein degradation.
• Cancer Research: Used to study tumor cell metastasis, drug resistance, and apoptosis, as V-ATPase inhibition can disrupt the acidic tumor microenvironment.
• Neuroscience Studies: Applied in research on neurotransmitter storage and release, as well as in models of neurodegenerative diseases where lysosomal dysfunction is implicated.
• Osteoclast Biology: Serves as a key inhibitor in studies of bone resorption, helping to elucidate mechanisms relevant to osteoporosis and related bone disorders.
• Antifungal & Antibiotic Studies: Used as a reference compound in microbiological research to explore new antimicrobial strategies based on proton pump inhibition.
• Cell Signaling Pathways: Employed to dissect signaling cascades that are pH-dependent or involve vesicular transport.

Basic Information

Product Name	Concanamycin G
CAS No.	144730-82-5
Molecular Formula	C46H75NO14
Molecular Weight	866.1 g/mol
Synonyms	Concanamycin G; Antibiotic X 4357B; V-ATPase Inhibitor Concanamycin G; Folimycin analog; 26-Deoxy-25-hydroxyconcanamycin A; (3E,5E,7R,8S,9S,10E,12E,14E,16R,18S,19S,20R,21S,22R,23S,24S,26R)-26-Deoxy-5,19,25-trihydroxy-4,6,8,10,12,14,16,18,20,22,24-undecamethyl-9-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2-oxo-27-oxa-3-azatricyclo[22.3.1.0¹⁰,¹⁴]octacosa-3,5,10,12,14,16,18,20,22,24-decaene-23-carboxylic acid
EINECS	Contact for details

Quality Control

Our Concanamycin G is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines
Biological Activity (IC50)	Specification available upon request

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.