Description

3-Bromo-2-Fluorobenzotrifluoride is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique combination of bromine and fluorine substituents, which enable precise structural modifications in complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry for structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atom for enhanced bioactivity and environmental stability.
• Material Science: Serves as a precursor for specialty polymers, liquid crystals, and electronic chemicals where the benzotrifluoride moiety imparts specific thermal and solubility properties.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings to construct complex biaryl systems.
• Fluorine Chemistry Research: An important reagent for investigating new fluorination methodologies and the effects of fluorine substitution on molecular properties.
• Chemical Intermediate: Employed in custom synthesis and contract manufacturing for producing tailored compounds for various high-tech applications.

Basic Information

Product Name	3-Bromo-2-Fluorobenzotrifluoride
CAS No.	144584-67-8
Molecular Formula	C7H3BrF4
Molecular Weight	242.99 g/mol
Synonyms	2-Fluoro-3-bromobenzotrifluoride; 1-Bromo-2-fluoro-3-(trifluoromethyl)benzene; 3-Bromo-2-fluoro-α,α,α-trifluorotoluene; 3-Bromo-2-fluoro-α,α,α-trifluoromethylbenzene; 2-Fluoro-3-bromo-α,α,α-trifluorotoluene; Benzene, 1-bromo-2-fluoro-3-(trifluoromethyl)-; 3-Bromo-2-fluorobenzylidynetrifluoride
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Fluorobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request. We are committed to meeting the stringent requirements of cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.5%
Water Content (KF)	≤ 0.5%
Density	~1.8 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.