Description

4-Bromo-2,2-Difluoro-1,3-Benzodioxole is a high-value halogenated benzodioxole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring bromine and fluorine substituents on the fused dioxole ring, makes it a versatile building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing halogenated benzodioxole motifs into drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form new carbon-carbon bonds.
• Fluorine Chemistry Research: Valuable substrate for studying the influence of gem-difluoro groups on the reactivity and stability of heterocyclic systems.
• Ligand and Catalyst Development: Used to synthesize novel chelating ligands or organocatalysts containing the benzodioxole scaffold.

Basic Information

Product Name	4-Bromo-2,2-Difluoro-1,3-Benzodioxole
CAS No.	144584-66-7
Molecular Formula	C7H3BrF2O2
Molecular Weight	236.99 g/mol
Synonyms	4-Bromo-2,2-difluoro-1,3-benzodioxole; 2,2-Difluoro-4-bromo-1,3-benzodioxole; 1,3-Benzodioxole, 4-bromo-2,2-difluoro-; 4-Bromo-2,2-difluorobenzo[d][1,3]dioxole; Benzo[1,3]dioxole, 4-bromo-2,2-difluoro-
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,2-Difluoro-1,3-Benzodioxole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.