Description

Squalestatin CAS NO 144541-82-2 is a potent and selective inhibitor of squalene synthase, a key enzyme in the cholesterol biosynthesis pathway. This compound is a critical research tool for studying lipid metabolism and has significant potential in the development of novel therapeutic agents targeting hypercholesterolemia and related metabolic disorders. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cardiovascular disease, metabolic syndrome, and antifungal drug discovery.

Application

• Biochemical Research: A fundamental tool for investigating the mevalonate pathway, sterol biosynthesis, and isoprenoid metabolism in vitro and in cell-based assays.
• Pharmaceutical Development: Serves as a lead compound or reference standard in the discovery and validation of new cholesterol-lowering drugs targeting squalene synthase.
• Antifungal Agent Research: Explored for its potential in developing new antifungal therapies, as inhibition of ergosterol synthesis (the fungal equivalent of cholesterol) is a validated drug target.
• Metabolic Disease Studies: Used in research models to understand the role of cholesterol synthesis in conditions like atherosclerosis, NAFLD (Non-Alcoholic Fatty Liver Disease), and type 2 diabetes.
• Enzyme Kinetics & Mechanism Studies: Employed to characterize the function and inhibition kinetics of the squalene synthase enzyme.
• Cell Biology: Used to modulate cellular cholesterol levels to study its impact on membrane fluidity, signal transduction, and protein prenylation.

Basic Information

Product Name	Squalestatin
CAS No.	144541-82-2
Molecular Formula	C29H44O6
Molecular Weight	488.66 g/mol
Synonyms	Zaragozic Acid A; Squalestatin 1; Zaragozic Acid; Squalestatin S1; ER-27856; L-669,262; (1R,2S,5S,6S,7S,8S,9S)-5,6,7,8,9-Pentahydroxy-2-[(1E,3E,5E,7E)-8-[(2S,3S)-3-hydroxy-2-methyl-5-oxotetrahydrofuran-2-yl]-2,6-dimethylocta-1,3,5,7-tetraenyl]-3-oxatricyclo[4.2.1.03,7]nonane-4-one
EINECS	Contact for details

Quality Control

Our Squalestatin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity determination, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A detailed Certificate of Analysis (COA) documenting all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.