Description

Concanamycin F is a potent and specific inhibitor of vacuolar-type H+-ATPase (V-ATPase), a key enzyme complex involved in intracellular pH regulation and membrane trafficking. This high-purity biochemical tool is essential for researchers investigating fundamental cellular processes such as autophagy, endocytosis, and receptor-mediated signaling. It is primarily utilized by scientists in the pharmaceutical, biotechnology, and academic research sectors for target validation and mechanistic studies in oncology, neurology, and infectious disease.

Application

• Biochemical Research: As a selective V-ATPase inhibitor to study intracellular acidification, organelle function, and protein degradation pathways.
• Cancer Research: Investigation of tumor cell metabolism, drug resistance mechanisms, and induction of apoptosis in various cancer cell lines.
• Neuroscience Studies: Exploration of neurotransmitter storage and release mechanisms in synaptic vesicles.
• Microbiology & Virology: Research into the role of endosomal acidification in pathogen entry and infection cycles.
• Drug Discovery: A reference compound for screening and developing novel therapeutics targeting V-ATPase in metabolic and bone diseases.
• Cell Biology: Tool for studying autophagy, lysosomal function, and membrane fusion events.

Basic Information

Product Name	Concanamycin F
CAS No.	144539-92-4
Molecular Formula	C46H75NO14
Molecular Weight	866.1 g/mol
Synonyms	Concanolide F; Antibiotic X 4357B; V-ATPase Inhibitor; 14-Deoxy-15-oxoconcanamycin F; (3E,5E,7E,9E,11E,13E,15E)-16-[(2R,3S,4S,5S,6R)-4-(Dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-5-ethyl-4,6,8,10,12,14,16-heptamethyl-17-oxooctadeca-3,5,7,9,11,13,15-heptaen-2-olide
EINECS	Contact for details

Quality Control

Our Concanamycin F is produced under stringent quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, potency, and stability data to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Biological Activity (IC50)	Specified per batch (COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.