Description

Concanamycin D CAS NO 144450-34-0 is a potent and specific macrolide antibiotic that functions as a highly selective inhibitor of vacuolar-type H+-ATPase (V-ATPase). This compound is a critical research tool for studying intracellular pH regulation, vesicular trafficking, and autophagy pathways in cell biology. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic studies, cancer research, and the development of novel therapeutic agents targeting lysosomal function.

Application

• Biochemical Research: A key reagent for investigating the role of V-ATPase in organelle acidification, protein degradation, and receptor-mediated endocytosis.
• Cancer Biology Studies: Used to explore the disruption of pH homeostasis in tumor cells and its impact on metastasis and drug resistance.
• Neuroscience Research: Applied in studies of neurotransmitter storage and release mechanisms within synaptic vesicles.
• Antimicrobial Mechanism Studies: Serves as a reference compound for understanding the action of macrolide antibiotics and exploring new antibacterial targets.
• Cell Signaling Pathways: Utilized to dissect signaling cascades that are dependent on lysosomal and endosomal activity.
• Pharmaceutical Development: Acts as a lead compound or pharmacological probe in early-stage drug discovery programs targeting osteoclast function and bone diseases.

Basic Information

Product Name	Concanamycin D
CAS No.	144450-34-0
Molecular Formula	C46H75NO14
Molecular Weight	866.1 g/mol
Synonyms	Concanamycin D; Antibiotic X 4357B; Folimycin; V-ATPase inhibitor Concanamycin D; NSC 328784; 28-Deoxy-25-demethyl-concanamycin A; (3E,5E,7E,9E,11E,13E,15E,17E,19E,21E,23E,25E,27E,29E)-38-Ethyl-3,5,7,9,11,13,15,17,19,21,23,25,27,29,31,33,35-heptadecaene-2,36-dihydroxy-4,6,8,10,12,14,16,18,20,22,24,26,28,30,32,34-hexadecaoxo-37-(2-oxoethyl)-1-oxa-4,7,10,13,16,19,22,25,28,31,34-undecaazacyclohexatriacontane-39-carboxylic acid
EINECS	Contact for details

Quality Control

Our Concanamycin D is produced under strict quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, potency, and other critical parameters to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Biological Activity	Confirmed by V-ATPase inhibition assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.