Description

3-Deoxy-3-Fluoroinositol 1,4,5-Trisphosphate is a fluorinated analog of the critical second messenger, inositol 1,4,5-trisphosphate (IP3), designed for advanced biochemical and pharmacological research. This compound is a vital tool for investigating calcium signaling pathways, serving as a potent antagonist to modulate IP3 receptor activity. It is primarily utilized by researchers and developers in pharmaceutical discovery, neurobiology, and cell signaling studies to elucidate disease mechanisms and develop novel therapeutic agents.

Application

• Biochemical Research: As a high-affinity antagonist for inositol 1,4,5-trisphosphate (IP3) receptors to study intracellular calcium (Ca²⁺) release and signaling cascades.
• Pharmacological Studies: Used in target validation and screening assays to develop novel therapeutics for conditions involving dysregulated calcium signaling, such as neurological disorders and cardiac diseases.
• Neurobiology: Investigation of synaptic transmission, neuronal plasticity, and the role of IP3 receptors in brain function and disease models.
• Cell Biology: Probing the mechanisms of cell proliferation, apoptosis, and hormone action where IP3-mediated pathways are involved.
• Enzyme Inhibition Studies: Serves as a substrate analog to study the specificity and kinetics of phosphatases and kinases within the inositol phosphate metabolism pathway.
• Diagnostic Development: Potential use in the development of assay kits and reagents for research and clinical diagnostics focused on calcium signaling biomarkers.

Basic Information

Product Name	3-Deoxy-3-Fluoroinositol 1,4,5-Trisphosphate
CAS No.	144371-38-0
Molecular Formula	C6H12FO15P3
Molecular Weight	508.06 g/mol
Synonyms	3-Deoxy-3-fluoro-D-myo-inositol 1,4,5-trisphosphate; 3-Fluoro-3-deoxy-IP3; 3-F-3-deoxy-IP3; 3-Fluoro-3-deoxyinositol 1,4,5-trisphosphate; Fluorinated IP3 analog; IP3 receptor antagonist; 3-Fluoro-IP3; myo-Inositol 1,4,5-trisphosphate 3-fluoro-3-deoxy analog
EINECS	Contact for details

Quality Control

Our 3-Deoxy-3-Fluoroinositol 1,4,5-Trisphosphate is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity, identity, and impurity profile. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and NMR, are validated to provide reliable and accurate data for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store under an inert atmosphere or desiccated conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.