Description

4-(1-Adamantyl)Benzenesulfonyl Chloride is a specialized organic intermediate featuring a rigid adamantyl group attached to a reactive benzenesulfonyl chloride moiety. This compound matters for its role as a key building block in the synthesis of advanced materials and pharmaceuticals, where its unique structure imparts desirable properties like enhanced stability and lipophilicity. It is primarily needed by research chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for creating novel sulfonamide derivatives and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the blood-brain barrier permeability often conferred by the adamantyl group.
• Agrochemical Synthesis: Used in the development of new-generation pesticides and herbicides, where the sulfonyl chloride group enables the introduction of sulfonamide functionalities with specific biological activity.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for creating high-performance polymers with enhanced thermal stability and chemical resistance for specialty coatings and engineering plastics.
• Material Science Research: Employed in the design and synthesis of advanced organic frameworks, metal-organic frameworks (MOFs), and other functional materials where precise molecular architecture is required.
• Chemical Biology Probes: Utilized to create sulfonylation reagents for labeling proteins or modifying biomolecules in proteomics and biochemical research.
• Catalyst Ligand Preparation: Acts as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	4-(1-Adamantyl)Benzenesulfonyl Chloride
CAS No.	144174-50-5
Molecular Formula	C16H19ClO2S
Molecular Weight	310.84 g/mol
Synonyms	4-(1-Adamantyl)benzenesulfonyl chloride; 1-[4-(Chlorosulfonyl)phenyl]adamantane; p-Adamantylbenzenesulfonyl chloride; 4-Adamant-1-ylbenzenesulfonyl chloride; NSC 405124; Adamantylphenylsulfonyl chloride; (4-Adamantan-1-ylphenyl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-(1-Adamantyl)Benzenesulfonyl Chloride is manufactured and tested under a strict quality management system. We ensure the product meets high-purity standards suitable for research and industrial synthesis. Comprehensive analytical testing, including HPLC, NMR, and FTIR, is performed to confirm identity and purity. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.