Description

Elacridar (CAS NO 143664-11-3) is a potent and highly selective third-generation P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor. This compound is critical for enhancing the bioavailability and efficacy of co-administered chemotherapeutic agents by overcoming multidrug resistance (MDR) in cancer cells. It is an essential research tool and pharmaceutical intermediate for oncology research, drug development, and preclinical studies targeting improved drug delivery and therapeutic outcomes.

Application

• Oncology Research: Used as a key pharmacological tool to study and overcome P-gp and BCRP-mediated multidrug resistance in various cancer cell lines and animal models.
• Drug Delivery Enhancement: Employed in preclinical studies to improve the oral bioavailability and brain penetration of co-administered anticancer drugs, such as paclitaxel and topotecan.
• Pharmaceutical Intermediates: Serves as a critical building block or reference standard in the synthesis and development of novel chemosensitizers and combination therapies.
• Mechanistic Studies: Facilitates research into the function and inhibition of ATP-binding cassette (ABC) transporters in pharmacokinetics and toxicology.
• Formulation Development: Applied in the development of advanced drug formulations and delivery systems aimed at bypassing efflux transporters.

Basic Information

Product Name	Elacridar
CAS No.	143664-11-3
Molecular Formula	C34H33N3O6
Molecular Weight	579.65 g/mol
Synonyms	GF120918; GW120918; N-(4-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide; Elacridar hydrochloride; P-gp/BCRP inhibitor; Chemosensitizer agent
EINECS	Contact for details

Quality Control

Our Elacridar is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.