Description

Ustiloxin A is a potent cyclic peptide mycotoxin produced by the rice false smut fungus, *Ustilaginoidea virens*. This compound is of significant interest in biochemical research due to its unique mechanism of action as a potent inhibitor of microtubule assembly, disrupting cell division. It serves as a critical reference standard and research tool for scientists in phytopathology, mycology, and anticancer drug discovery programs, enabling the study of fungal virulence and the development of novel therapeutic agents.

Application

• Phytopathological Research: Used as a key analytical standard to study the biosynthesis, toxicity, and environmental fate of Ustiloxin A produced by *Ustilaginoidea virens* in infected crops.
• Mycotoxin Analysis: Serves as a certified reference material (CRM) for the accurate quantification and confirmation of Ustiloxin A contamination in food safety laboratories, ensuring regulatory compliance for grains like rice.
• Biochemical Mechanism Studies: Employed in cell biology and pharmacology research to investigate its specific inhibitory effects on tubulin polymerization and microtubule dynamics.
• Anticancer Research: Utilized as a lead compound or probe in preclinical studies to evaluate its potential as an antimitotic agent for oncology drug development.
• Fungicide Development: Acts as a target molecule for screening and developing novel antifungal agents or resistance management strategies against rice false smut.
• Academic & Institutional Research: Provides a high-purity compound for universities and research institutes conducting studies on natural products, fungal metabolites, and cell cycle inhibitors.

Basic Information

Product Name	Ustiloxin A
CAS No.	143557-93-1
Molecular Formula	C₂₈H₃₈N₆O₈
Molecular Weight	586.64 g/mol
Synonyms	Ustiloxin A; Ustiloxin; Cyclo[(2S,3S,6S)-3-hydroxy-6-[(1S)-1-hydroxyethyl]-2-methyl-1-oxo-1,2,3,6-tetrahydro-4,1-benzoxazepin-7-yl]-L-alanyl-(3R)-3-hydroxy-L-valyl-(Z)-2,3-didehydro-2-aminobutanoyl-; (3S,6S,9S,12S,18S,21S,24S,28S)-3,6,21,24-Tetrakis(hydroxymethyl)-9-[(1S)-1-hydroxyethyl]-12,18-dimethyl-1,4,7,10,13,16,19,22,25-nonaazacyclooctacosane-2,5,8,11,14,17,20,23,26-nonaone
EINECS	Contact for details

Quality Control

Our Ustiloxin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) containing lot-specific data is provided to guarantee it meets the stringent requirements for use as a reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.