Description

n-(R)-[2-(Hydroxyaminocarbonyl)Methyl]-4-Methylpentanoyl-L-Naphthylalanyl-L-Alanine Amide is a specialized synthetic peptide derivative of significant interest in advanced pharmaceutical research. This compound is valued for its role as a key intermediate or active component in the development of novel therapeutic agents, particularly those targeting enzymatic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of peptide-based drugs, enzyme inhibitors, and diagnostic probes. Its precise stereochemistry and functional groups make it a critical building block for creating molecules with high biological specificity.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Enzyme Inhibitor Research: Used in biochemical assays and research to study enzyme inhibition mechanisms, particularly for proteases and metalloproteinases.
• Bioconjugation & Probe Development: Acts as a scaffold or linker for creating targeted bioconjugates, fluorescent probes, or affinity labels for diagnostic and research applications.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of therapeutic peptides.
• Biochemical Tool Compound: Utilized as a reference standard or tool compound in high-throughput screening (HTS) and pharmacological profiling.

Basic Information

Product Name	n-(R)-[2-(Hydroxyaminocarbonyl)Methyl]-4-Methylpentanoyl-L-Naphthylalanyl-L-Alanine Amide
CAS No.	143457-40-3
Molecular Formula	C26H34N4O5
Molecular Weight	482.57 g/mol
Synonyms	N-[(2R)-2-[(2S)-2-[[(2S)-2-[(2-Amino-2-oxoethyl)amino]-1-oxo-2-[(1R)-2-methylpropyl]ethyl]amino]-2-(naphthalen-1-yl)acetyl]amino]propanoyl]hydroxylamine; TAPI-2; TNF-α Protease Inhibitor-2; TNF-alpha Protease Inhibitor 2; TAPI 2; (R)-2-((S)-2-((S)-2-(2-(Hydroxyamino)-2-oxoacetamido)-4-methylpentanamido)-2-(naphthalen-1-yl)acetamido)propanamide; Hydroxamic acid-based MMP inhibitor
EINECS	Contact for details

Quality Control

Our n-(R)-[2-(Hydroxyaminocarbonyl)Methyl]-4-Methylpentanoyl-L-Naphthylalanyl-L-Alanine Amide is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines to support our clients in preclinical and development phases. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability, as the compound is easily oxidized. For short-term use, it may be stored at 2-8°C. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.